Non-invasive prenatal genetic test

Nova Clinic is glad to offer their patients a genetic screening for fetal chromosomal mutations through the analysis of the mother’s blood sample with the help of next-generation sequencing (NGS) technique.

Non-invasive genetic test helps detect most wide-spread chromosomal pathologies:

• Down’s syndrome
• Edwards' syndrome
• Patau's syndrome
• Klinefelter's syndrome
• Turner's syndrome

A patient receives the geneticist’s medical conclusion as well as the results of the test.

Advantages of non-invasive prenatal test

• Safety

There is no contact with an embryo’s membrane, which, otherwise, may cause miscarriages or other complications. A venous blood sample collected from a woman is quite enough to perform the test. All these are safe both for the mother and the fetus.

• High accuracy

The non-invasive test uses fetal DNA, which, unlike an ultrasound and a biochemical screening, is a direct diagnostic technique with accuracy up to 99,9%. It should be also noted that the percentage of inaccurate (false-positive) results is inferior than 0,1% .

Indications

The test can be recommended to all pregnant women who want to obtain additional information on their babies’ health condition. However, the test is usually recommended to women running a high risk of having a baby with chromosomal mutations:

• when a women is over 35
• when a man is over 42
• ultrasound or a biochemical screening indicate to a high risk of developing a chromosomal pathology
• balanced chromosomal alteration has been found in one of the parents

Restrictions on a non-invasive prenatal diagnosis

• pregnancy term is less than 10 weeks
• multifetal pregnancy
• blood transfusion (over two recent years)
• organ transplant operations or treatment with stem cells
• oncological diseases
• IVF with donor egg cells
• surrogacy

Non-invasive prenatal diagnosis includes the following steps

• collection of a venous blood sample
• blood sample screening for fetal chromosomal pathologies
• calculation of an individual risk of having a baby with chromosomal mutations
• geneticist’s medical conclusion on the mother’s health condition